Syringocystadenoma papilliferum
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Syringocystadenoma papilliferum is a rare non-malignant adnexal neoplasm that develops from apocrine or eccrine sweat glands and can be identified histologically by cystic, papillary, and ductal invaginations into the dermis lined by double-layered outer cuboidal and luminal high columnar epithelium and connected to the epidermis.[1]
Syringocystadenoma papilliferum | |
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Other names | Syringadenoma papilliferum, Fistulous vegetative verrucous hydradenoma, Naevus syringocystadenomatosus papilliferus, Papillary syringocystadenoma, and SCAP. |
An example of a syringocystadenoma papilliferum | |
Specialty | Dermatology |
Usual onset | Childhood, Neonatal, Infancy, Adolescent.[1] |
Causes | Genetic.[2] |
Diagnostic method | Skin biopsy.[3] |
Differential diagnosis | Hidradenoma papilliferum, Papillary eccrine adenoma, Warty dyskeratoma, Tubular apocrine adenoma, Syringocystadenocarcinoma papilliferum.[3] |
Treatment | Surgical excision.[3] |
Lesions have a heterogeneous, non-distinctive appearance that ranges from skin-colored to pink-colored papules or plaques. Typically, lesions form in the head and neck area.[1]
Syringocystadenoma papilliferum can develop de-novo or within a nevus sebaceous.[4] Syringocystadenoma papilliferum tends to be seen in children. It is present at birth in approximately 50% of individuals affected, and it develops before puberty in the remaining 15%-30%.[4]