Biliverdin reductase
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Biliverdin reductase (BVR) is an enzyme (EC 1.3.1.24) found in all tissues under normal conditions, but especially in reticulo-macrophages of the liver and spleen. BVR facilitates the conversion of biliverdin to bilirubin via the reduction of a double bond between the second and third pyrrole ring into a single bond.
Quick Facts Identifiers, EC no. ...
biliverdin reductase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.24 | ||||||||
CAS no. | 9074-10-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
biliverdin reductase A | |||||||
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Identifiers | |||||||
Symbol | BLVRA | ||||||
Alt. symbols | BLVR | ||||||
NCBI gene | 644 | ||||||
HGNC | 1062 | ||||||
OMIM | 109750 | ||||||
RefSeq | NM_000712 | ||||||
UniProt | P53004 | ||||||
Other data | |||||||
EC number | 1.3.1.24 | ||||||
Locus | Chr. 7 p14-cen | ||||||
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Quick Facts Identifiers, Symbol ...
biliverdin reductase B | |||||||
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Identifiers | |||||||
Symbol | BLVRB | ||||||
Alt. symbols | FLR | ||||||
NCBI gene | 645 | ||||||
HGNC | 1063 | ||||||
OMIM | 600941 | ||||||
RefSeq | NM_000713 | ||||||
UniProt | P30043 | ||||||
Other data | |||||||
EC number | 1.3.1.24 | ||||||
Locus | Chr. 19 q13.1-13.2 | ||||||
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Quick Facts Identifiers, Symbol ...
Biliverdin reductase, catalytic | |||||||||
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Identifiers | |||||||||
Symbol | Biliv-reduc_cat | ||||||||
Pfam | PF09166 | ||||||||
InterPro | IPR015249 | ||||||||
SCOP2 | 1lc0 / SCOPe / SUPFAM | ||||||||
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There are two isozymes in humans, each encoded by its own gene, biliverdin reductase A (BLVRA) and biliverdin reductase B (BLVRB).